AZD-7762 hydrochloride

C₁₇H₁₉FN₄O₂S · HCl

398.88

MFCD12546135

329825353

NA.77

AZD-7762 hydrochloride has been used:

• as a checkpoint kinase 1 and 2 (CHK1/2) inhibitor to study its effect on the efficiency of non-homologous end-joining (NHEJ) repair in breast cancer cell lines
• as a CHK1 inhibitor to serve as a positive control for replication stress in the assessment of fork restart events
• as a CHK1/2 inhibitor to study its effects on DNA lesions during mice zygote development

AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2 that enhanced cytotoxicity DNA-damaging agents.

100

≥98% (HPLC)

powder

desiccated

white to light brown

DMSO: 15 mg/mL, clear

−20℃

Cl.NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)-c3cccc(F)c3

1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1H/t12-;/m0./s1

WFZBLOIXZRZEDG-YDALLXLXSA-N

5, 25 mg in glass bottle

GHS05,GHS07

Danger

H302 - H318

P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310

Acute Tox. 4 Oral - Eye Dam. 1

11 - Combustible Solids

WGK 3