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Azoramide
产品别名
932986-18-0
Azoramide
N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]-butanamide
N-{2-[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]ethyl} butanamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H17ClN2OS |
| Molecular weight | 308.83 |
| MDL number | MFCD08009374 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825964 |
| Biochem/physiol Actions【生化/生理作用】 | Azoramide is a modulator of the unfolded protein response with antidiabetic activity. It has dual activity: Azoramide improves endoplasmic reticulum (ER) protein-folding ability and stimulates the expression of ER chaperones that protect cells against ER stress. Azoramide was shown to protect cells from death and dysfunction in multiple models of ER stress. It showed antidiabetic activity in two independent mouse models of obesity by improving insulin sensitivity and protecting pancreatic β cell function against ER stress. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 30 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | ClC1=CC=C(C2=NC(CCNC(CCC)=O)=CS2)C=C1 |
| InChI | 1S/C15H17ClN2OS/c1-2-3-14(19)17-9-8-13-10-20-15(18-13)11-4-6-12(16)7-5-11/h4-7,10H,2-3,8-9H2,1H3,(H,17,19) |
| InChI key | VYBFWKKCWTXCQX-UHFFFAOYSA-N |
| packaging【包装】 | 10, 50 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
