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BAY 41-2272
产品别名
BAY 41-2272
3-(4-Amino-5-cyclopropylpyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H17FN6 |
| Molecular weight | 360.39 |
| MDL number | MFCD06411391 |
| PubChem Substance ID【PubChem化学物质编号】 | 24892096 |
| NACRES | NA.77 |
| Application【应用】 | BAY 41-2272 has been used for the stimulation of guanylate cyclase in heart and neurons. |
| Biochem/physiol Actions【生化/生理作用】 | BAY 41-2272 is an activator of soluble guanylate cyclase at a novel, NO-independent regulatory site. BAY 41-2272 is the first product that stimulates sGC through a non-NO mechanism. BAY 41-2272 inhibits platelet aggregation and induces vasorelaxation without nitrate tolerance. |
| Features and Benefits【特点和优势】 | This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to light brown |
| mp | 210.5-211.4 ℃ |
| solubility【溶解性】 | DMSO: 5 mg/mL, clear (warmed) |
| originator【创始人】 | Bayer |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Nc1nc(ncc1C2CC2)-c3nn(Cc4ccccc4F)c5ncccc35 |
| InChI | 1S/C20H17FN6/c21-16-6-2-1-4-13(16)11-27-20-14(5-3-9-23-20)17(26-27)19-24-10-15(12-7-8-12)18(22)25-19/h1-6,9-10,12H,7-8,11H2,(H2,22,24,25) |
| InChI key | ATOAHNRJAXSBOR-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
