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BGP-15
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H22N4O2· 2HCl |
| Molecular weight | 351.27 |
| MDL number | MFCD21603901 |
| PubChem Substance ID【PubChem化学物质编号】 | 329773244 |
| NACRES | NA.77 |
| General description【一般描述】 | BGP-15 is a hydroxylamine derivative, which has cytoprotective and neuroprotective properties. It reduces phospho- c-Jun N-terminal kinase (pJNK) and p38 stress signalling. BGP-15 also stimulates non-specific serine/threonine protein kinase (AKT) and insulin-like growth factor 1 receptor (IGFR1) protective signalling. BGP-15 functions as an insulin sensitizer in an olanzapine-induced metabolic disorder. It protects cells against cell death and enhances the expression of heat shock protein (HSP). BGP-15 might be used to treat heart failure (HF) and atrial fibrillation (AF). |
| Application【应用】 | BGP-15 has been used to study its influence on proteasomal degradation of missense dystrophins. |
| Biochem/physiol Actions【生化/生理作用】 | BGP-15 is PARP inhibitor, HSP72 activator. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| solubility【溶解性】 | deionized water: 28 mg/mL |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | Cl.Cl.N\C(=N/OCC(O)CN1CCCCC1)c2cccnc2 |
| InChI | 1S/C14H22N4O2.2ClH/c15-14(12-5-4-6-16-9-12)17-20-11-13(19)10-18-7-2-1-3-8-18;;/h4-6,9,13,19H,1-3,7-8,10-11H2,(H2,15,17);2*1H |
| InChI key | ISGGVCWFTPTHIX-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS06 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P264 - P270 - P301 + P310 - P405 - P501 |
| Hazard Classifications【危险分类】 | Acute Tox. 3 Oral |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
