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比生群二盐酸盐
Bisantrene dihydrochloride
产品别名
78186-34-2
比生群二盐酸盐
Bisantrene dihydrochloride
Bis((4,5-dihydro-1H-imidazol-2-yl)hydrazone)-9,10-anthracenedicarboxaldehyde dihydrochloride
NSC 337766
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H22N8 ·2HCl |
| Molecular weight | 471.39 |
| MDL number | MFCD01743164 |
| PubChem Substance ID【PubChem化学物质编号】 | 329773240 |
| NACRES | NA.77 |
| Application【应用】 | Bisantrene (NSC 337766), and its derivatives are topoisomerase II poisons and DNA intercalators. It may be used as model compounds to study P-glycoprotein-mediated multiple drug resistance (MDR1). Bisantrene may be used as a Rac1 inhibitor. |
| Biochem/physiol Actions【生化/生理作用】 | Bisantrene dihydrochloride is an antineoplastic agent, MDR1 substrate, DNA intercalator, and topoisomerase II poison. Cancer cells that develop resistance to bisantrene tend to overexpress P-glycoprotein. Bisantrene can be used to select for P-glycoprotein-mediated multiple drug resistance. The data suggest that bisantrene is an excellent substrate for P-glycoprotein. Bisantrene is an anthracene bishydrazone derivative, which has antitumor activity. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| solubility【溶解性】 | deionized water: 8 mg/mL |
| storage temp.【储存温度】 | room temp |
| SMILES string | Cl.Cl.C1CN=C(N1)N\N=C\c2c3ccccc3c(\C=N\NC4=NCCN4)c5ccccc25 |
| InChI | 1S/C22H22N8.2ClH/c1-2-6-16-15(5-1)19(13-27-29-21-23-9-10-24-21)17-7-3-4-8-18(17)20(16)14-28-30-22-25-11-12-26-22;;/h1-8,13-14H,9-12H2,(H2,23,24,29)(H2,25,26,30);2*1H/b27-13+,28-14+;; |
| InChI key | KINULKKPVJYRON-PVNXHVEDSA-N |
| packaging【包装】 | 10, 50 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07,GHS09 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 - H400 |
| Precautionary Statements | P273 - P301 + P312 + P330 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Aquatic Acute 1 |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
