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Bisindolylmaleimide X hydrochloride
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产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
3415362 | 1 MG | 1430 |
产品别名
145317-11-9
Bisindolylmaleimide X hydrochloride
Ro 31-8425
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C26H24N4O2 · HCl |
Molecular weight | 460.96 |
MDL number | MFCD04972010 |
PubChem Substance ID【PubChem化学物质编号】 | 329773224 |
NACRES | NA.77 |
Application【应用】 | Bisindolylmaleimide X hydrochloride has been used as a protein kinase C (PKC) inhibitor:
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Biochem/physiol Actions【生化/生理作用】 | Bisindolylmaleimide X hydrochloride/Ro 31-8425, a strong and selective protein kinase C (PKC) inhibitor, can reduce the superoxide burst caused by various agonists in neutrophils. It can suppress the responses induced by cell surface receptors and phorbol esters in T cells. In humans, Ro 31-8425 can prevent neutrophil PKC in vitro with an IC50 of 5nM. |
产品性质
Quality Level【质量水平】 | 200 |
biological source【生物来源】 | synthetic (organic) |
Assay【测定】 | ≥90% |
form【形式】 | solid |
solubility【溶解性】 | DMSO: soluble |
storage temp.【储存温度】 | −20℃ |
SMILES string | Cl.Cn1cc(C2=C(C(=O)NC2=O)c3c4CC(CN)CCn4c5ccccc35)c6ccccc16 |
InChI | 1S/C26H24N4O2.ClH/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30;/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32);1H |
InChI key | IMBOYWXMTUUYGZ-UHFFFAOYSA-N |
安全信息
Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
WGK | WGK 3 |
Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |