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BMS-341400 甲磺酸酯
BMS-341400 methanesulfonate
产品别名
296250-54-9
BMS-341400 甲磺酸酯
BMS-341400 methanesulfonate
1-[9-[[(3-Chloro-4-methoxyphenyl)methyl]amino]-3-ethyl-3H-pyrazolo[4′,3′:5,6]pyrido[3,4-d]pyridazin-6-yl]-N-methyl-H-imidazole-4-carboxamide methanesulfonate (1:1)
1-[9-[[(3-Chloro-4-methoxyphenyl)methyl]amino]-3-ethyl-3Hpyrazolo[4′,3′:5,6]pyrido[3,4-d]pyridazin-6-yl]-4-methylimidazolecarboxamide methanesulfonate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C23H22ClN9O2 · CH4O3S |
| Molecular weight | 588.04 |
| PubChem Substance ID【PubChem化学物质编号】 | 329774349 |
| Biochem/physiol Actions【生化/生理作用】 | BMS-341400 is a selective and potent phosphodiesterase 5 (PDE 5) inhibitor. BMS-341400 has an IC50 value of 0.3 nM and is 150-fold selective for PDE5 over PDE6 and over 10,000-fold selective for PDE5 over PDE1, PDE2, PDE3, and PDE4. |
| Features and Benefits【特点和优势】 | BMS-341400 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS. |
| Legal Information【法律信息】 | Sold for research purposes only under agreement from BMS. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 20 mg/mL, clear |
| storage temp.【储存温度】 | room temp |
| SMILES string | O=S(C)(O)=O.ClC1=CC(CNC2=C(C(C=NN3CC)=C3N=C4)C4=C(N5C=NC(C(NC)=O)=C5)N=N2)=CC=C1OC |
| InChI | 1S/C23H22ClN9O2.CH4O3S/c1-4-33-21-15(10-29-33)19-14(9-27-21)22(32-11-17(28-12-32)23(34)25-2)31-30-20(19)26-8-13-5-6-18(35-3)16(24)7-13;1-5(2,3)4/h5-7,9-12H,4,8H2,1-3H3,(H,25,34)(H,26,30);1H3,(H,2,3,4) |
| InChI key | NTAGDQYHYAUFMS-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
