C-Peptide EIA Kit

NA.32

The C-Peptide Enzyme Immunoassay (EIA) Kit is an in vitro quantitative assay for detecting C-Peptide peptide based on the principle of Competitive Enzyme Immunoassay. EIA-CPE-1 only detects C-peptide, not Insulin A or B chain.

C-Peptide , synthetic peptide

请参考Protocol了解详情。

C-peptide inhibits endothelial dysfunction under high glucose conditions via inhibition of nuclear factor-κB (NF-κB) pathway. Experimental studies suggest that prolonged dosage of physiological concentration of C-peptide to type 1 diabetes patients minimizes diabetes-induced complications, such as glomerular hypertrophy and mesangial matrix expansion by interrupting transforming growth factor β1 (TGF-β1) and tumor necrosis factor α (TNFα) signaling pathway. C-peptide reduces diabetes-induced glomerular hyperfiltration by contraction of the afferent arteriole, dilation of the efferent arteriole, and by inhibition of tubular reabsorption. C-Peptide also plays a crucial role in renal pathophysiology. C-peptide binds to a cell surface receptor that is likely to be G-protein coupled. This interaction stimulates various cellular functions such as increasing intracellular Ca²⁺ concentration, enhancing PI3-K (phosphoinositide 3-kinase) activity, increased endothelial nitric oxide synthase (eNOS) transcription, and activation of the Na⁺/K⁺ ATPase and mitogen-activated protein kinase (MAPK) signaling pathway.

组份可单独销售
RABHRP3 HRP-Streptavidin

human, rat, mouse

kit of 96 wells (12 strips x 8 wells)

ELISA: suitable
enzyme immunoassay: suitable

sample type cell lysate
sample type culture supernatant(s)
sample type plasma
sample type serum

inter-assay cv: <15%
intra-assay cv: <10%
sensitivity: 772 pg/mL
standard curve range: 0.1-1000 ng/mL

colorimetric

wet ice

−20℃

human ... INS(3630)

GHS05

Warning

H290

P234 - P390

Met. Corr. 1

8A - Combustible, corrosive hazardous materials

WGK 3