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Carcinine 二盐酸盐
Carcinine dihydrochloride
产品别名
57022-38-5
Carcinine 二盐酸盐
Carcinine dihydrochloride
Beta-Alanylhistamine dihydrochloride
3-Amino-N-[2-(1H-imidazol-4-yl)ethyl]propanamide dihydrochloride
β-Alanylhistamine dihydrochloride
Alistin
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C8H14N4O · 2HCl |
| Molecular weight | 255.14 |
| MDL number | MFCD22200567 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825334 |
| NACRES | NA.77 |
| General description【一般描述】 | Carcinine, a natural peptide derivative, with a β-alanyl residue and a histamine, carries an imidazole ring. In mammals, carcinine is present in the brain, muscle, intestine and liver tissues. |
| Application【应用】 | Carcinine dihydrochloride has been used to study its effects on dopaminergic neuron degeneration. |
| Biochem/physiol Actions【生化/生理作用】 | Carcinine (β-alanyl histamine) is a selective histamine H3 antagonist, 100-1000-fold selective for H3 over H2 and H1, that also functions as an antioxidant and as a chemical chaperone to reduce non-enzymatic glycation of proteins and maintain native folding of proteins. Carcinine can scavenge a toxic product, called 4-hydroxynonenal (4-HNE), obtained during lipid oxidation. It has a protective role from oxidative damage on photoreceptor cells. Carcinine also exhibits lipid-peroxidase activity. |
| Features and Benefits【特点和优势】 | This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to beige |
| solubility【溶解性】 | H2O: >15 mg/mL |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | Cl.Cl.NCCC(=O)NCCc1cnc[nH]1 |
| InChI | 1S/C8H14N4O.2ClH/c9-3-1-8(13)11-4-2-7-5-10-6-12-7;;/h5-6H,1-4,9H2,(H,10,12)(H,11,13);2*1H |
| InChI key | ZQTUNIWBUQUKAM-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS05,GHS07 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H315 - H318 - H335 |
| Precautionary Statements | P280 - P302 + P352 - P305 + P351 + P338 + P310 |
| Hazard Classifications【危险分类】 | Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
