Cardiotoxicity Ligand Set

NA.77

A set of 52 compounds are arranged in 96-well format, one compound per well (250 μl at 10 mM in DMSO)

Cardiotoxicity Ligand Set has been used in the cumulative drug dosage studies on engineered human induced pluripotent stem cell-derived cardiomyocyte (hiPS-CM) tissues.

Cardiotoxicity is an important cause for concern in drug development and appears to cut across therapeutic indications and drug classes. Several drugs have been removed from the market recently because of prolonging the QT interval or causing Torsades de Pointes (TdP).

The Cardiotoxicity Ligand Set features a wide variety of drugs including anti-arrhythmics, antihistamines, antibiotics, anticonvulsants, antidepressants and antipsychotics that are known to have cardiotoxic side-effects.

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
SDFile provided to construct a database containing:

• Structure
• Primary Name
• Secondary Name
• Pharmacological Activity
• Product Number
• Rack Position

dry ice

−20℃

GHS07,GHS08,GHS09

Danger

H302 - H350 - H360FD - H362 - H411

P202 - P263 - P264 - P273 - P301 + P312 - P308 + P313

Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 1A - Lact. - Repr. 1B

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK 3