CCT007093

C₁₅H₁₂OS₂

272.39

MFCD00121546

329775204

NA.77

CCT007093 has been used as a wild-type p53-induced phosphatase (Wip1) inhibitor to study its effect on skin keratinocytes, under ultra-violet (UV) stress conditions. It has also been used as a Wip1 inhibitor in time course inhibition assay to evaluate the effect of Wip1 inhibition on expression of AKT serine/threonine kinase 1(Akt1) and glycogen synthase kinase-3β (GSK-3β)and the phosphorylation of GSK-3β at serine 9 (Ser9) and Akt at Ser473.

CCT007093 inhibits the growth of cancer cell lines (MCF-7, KPL-1, and MCF-3B) that overexpress protein phosphatase, Mg²⁺/Mn²⁺ dependent 1D (PPM1D). It induces cancer cell death via the activation of p38 kinase activity.
CCT007093 is an effective protein phosphatase, Mg²⁺/Mn²⁺ dependent, 1D (PPM1D) inhibitor that selectively reduces viability of human tumour cell lines.

This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

100

≥98% (HPLC)

powder, yellow

DMSO: >3 mg/mL

2-8℃

O=C1\C(CC\C1=C/c2cccs2)=C\c3cccs3

1S/C15H12OS2/c16-15-11(9-13-3-1-7-17-13)5-6-12(15)10-14-4-2-8-18-14/h1-4,7-10H,5-6H2/b11-9+,12-10+

KPFZCKDPBMGECB-WGDLNXRISA-N

5, 25 mg in glass bottle

GHS07

Warning

H315 - H319 - H335

P302 + P352 - P305 + P351 + P338

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Respiratory system

11 - Combustible Solids

WGK 3

dust mask type N95 (US), Eyeshields, Gloves