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CD152/Fc Chimera, Non-cytolytic from mouse
| 产品编号： | 3423820 |
| 规格： | ≥98% (SDS-PAGE), recombinant, expressed in NS.1 cells, lyophilized |
| 包装规格： | 1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
CD152/Fc Chimera, Non-cytolytic from mouse
CTLA4/Fc Chimera, non-cytolytic
基本信息
| MDL number | MFCD01092888 |
| NACRES | NA.32 |
| General description【一般描述】 | The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain in which mutations to the complement (C1q) and FcγR I binding sites of the Fcγ2a fragment render the Fc fusion protein incapable of direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC). |
| Biochem/physiol Actions【生化/生理作用】 | CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86. |
| Physical form【外形】 | Lyophilized from solution of 0.2 μm filtered, in phosphate buffered saline, pH 7.4, with no preservative added. |
| Preparation Note【制备说明】 | Purified from serum-free tissue culture supernatant |
产品性质
| Quality Level【质量水平】 | 200 |
| recombinant【重组】 | expressed in NS.1 cells |
| Assay【测定】 | ≥98% (SDS-PAGE) |
| form【形式】 | lyophilized |
| mol wt【分子量】 | 97 kDa |
| UniProt accession no.【UniProt登记号】 | P09793 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | mouse ... Ctla4(12477) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
