CD40L, Soluble mouse

NA.32

CD40L (cluster of differentiation 40 ligand), a member of TNF (tumor necrosis factor) superfamily, is a membrane bound protein. This protein is predominantly expressed transiently by activated CD4⁺ T cells either as a cell-surface molecule or a secreted multimer protein. Activated B cells, certain DC (dendritic cell) subsets, platelets, and smooth muscle cells also express this protein.

CD40L (cluster of differentiation 40 ligand) interacts with its receptor CD40 which in turn helps mediate the interaction between APCs (antigen presenting cells) and lymphocytes. Activated platelets produce CD40L which then participates in multiple processes such as endothelial cell reactions, formation of germinal center, T-helper cell priming, and cytotoxic T-cell activation. Platelets are also involved in the pathogenesis of asthma through CD40L where they inhibit the production of regulatory T-cells and promote polarization of T-helper cells. Studies in mice show that this protein confers protection against influenza virus, though in a CD4⁺ T cell independent manner.

Lyophilized from PBS.

Reconstitute with 100 μL deionized water.

Mouse CD40L (aa 115-260) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG^®-tag.

FLAG is a registered trademark of sigma-aldrich Co. LLC

mouse

expressed in CHO cells

FLAG^® tagged

>95% (SDS-PAGE)

lyophilized

35-40 kDa

pkg of 10 μg

avoid repeated freeze/thaw cycles

<0.01 EU/μg endotoxin, tested

P27548

wet ice

−20℃

mouse ... Cd40lg(21947)

12 - Non Combustible Liquids

WGK 2