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环己喹酰胺
Cilostamide
| 产品编号： | 3425928 |
| 规格： | phosphodiesterase inhibitor |
| CAS NO： | 68550-75-4 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3425928 | 5 MG | 5450 |
产品别名
68550-75-4
环己喹酰胺
Cilostamide
OPC 3689
6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H26N2O3 |
| Molecular weight | 342.43 |
| MDL number | MFCD00673958 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278337 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC50 = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation. PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures. Cilostamide is known to delay meiotic progression. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | powder |
| solubility【溶解性】 | DMSO: 20 mg/mL, clear, colorless to faintly yellow |
| SMILES string | CN(C1CCCCC1)C(=O)CCCOc2ccc3NC(=O)C=Cc3c2 |
| InChI | 1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23) |
| InChI key | UIAYVIIHMORPSJ-UHFFFAOYSA-N |
| Gene Information | human ... PDE3A(5139), PDE3B(5140), PDE5A(8654), PDE7A(5150) rat ... Pde2a(81743), Pde4a(25638) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
