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CJ-13610
产品别名
179420-17-8
CJ-13610
Tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H23N3O2S |
| Molecular weight | 393.50 |
| MDL number | MFCD00948114 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825216 |
| NACRES | NA.77 |
| Application【应用】 | CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling. |
| Biochem/physiol Actions【生化/生理作用】 | CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA expression in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tetrachloride-treated mice. CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC50 = 70 nM). |
| Features and Benefits【特点和优势】 | This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to tan |
| solubility【溶解性】 | DMSO: ≥10 mg/mL |
| originator【创始人】 | Pfizer |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cc1nccn1-c2ccc(Sc3cccc(c3)C4(CCOCC4)C(N)=O)cc2 |
| InChI | 1S/C22H23N3O2S/c1-16-24-11-12-25(16)18-5-7-19(8-6-18)28-20-4-2-3-17(15-20)22(21(23)26)9-13-27-14-10-22/h2-8,11-12,15H,9-10,13-14H2,1H3,(H2,23,26) |
| InChI key | VPTONMHDLLMOOV-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
