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Clasto-乳胞素 β-内酯
clasto-Lactacystin β-lactone
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3426546 | 0.1 MG | 5060 |
产品别名
154226-60-5
Clasto-乳胞素 β-内酯
clasto-Lactacystin β-lactone
(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-Oxa-2-Azabicyclo[3.2.0]Heptane-3,7-Dione
Omuralide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C10H15NO4 |
| Molecular weight | 213.23 |
| MDL number | MFCD01076526 |
| PubChem Substance ID【PubChem化学物质编号】 | 24896450 |
| NACRES | NA.77 |
| Application【应用】 | Clasto-Lactacystin β-lactone has been used as a protein degradation inhibitor to test its effect on memory improvements in mice. It has also been used as a proteasome inhibitor in human ovarian surface epithelium (HOSE) cells and dendritic cells (DCs). Clasto-乳胞素 β-内酯用作蛋白酶体抑制剂。 |
| Biochem/physiol Actions【生化/生理作用】 | 细胞渗透性和不可逆蛋白酶体抑制剂。乳胞素作为染色体断裂-乳胞素 β 的前体-内酯。 Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii by acting in the N-threonine residue of the β -type subunits. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | film |
| solubility【溶解性】 | DMSO: soluble 25 mg/mL |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | [H][C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2C)[C@@H](O)C(C)C |
| InChI | 1S/C10H15NO4/c1-4(2)6(12)10-7(15-9(10)14)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10-/m1/s1 |
| InChI key | FWPWHHUJACGNMZ-NBBQQVJHSA-N |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P264 - P280 - P305 + P351 + P338 - P337 + P313 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
