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克立咪唑 盐酸盐
Clemizole hydrochloride
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3426615 | 5 MG | 1100 | |||
| 3426615 | 25 MG | 4050 |
产品别名
1163-36-6
克立咪唑 盐酸盐
Clemizole hydrochloride
1-(p-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)benzimidazole hydrochloride
1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride
1-(p-Chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole hydrochloride
CID 2782 hydrochloride
NSC 46261 hydrochloride
1-对氯苄基-2-(1-吡咯烷基)甲基苯并咪唑 盐酸盐
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H20ClN3 · HCl |
| Molecular weight | 362.30 |
| EC number【EC 号】 | 214-605-4 |
| MDL number | MFCD00051435 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825887 |
| General description【一般描述】 | Clemizole is a potent anti-allergic drug. |
| Biochem/physiol Actions【生化/生理作用】 | Clemizole is an antihistamine and an inhibitor of NS4B (nonstructural protein 4B) RNA of HCV (hepatitis C virus). Studies in Scn1α (sodium channel, voltage-gated, type I, α) Zebrafish mutant show that this drug has the potential as a therapeutic agent in Dravet Syndrome treatment. Clemizole is a potent and preferring inhibitor of TRPC5 that efficiently blocks heterologously expressed homomeric TRPC5 channels as well as heteromeric TRPC1:TRPC5 channels. Clemizole is a potent and selective H1 histamine receptor antagonist. Clemizole inhibited binding of HCV RNA by NS4B inhibit HCV RNA replication in cell culture. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | H2O: 2 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | ClC(C=C1)=CC=C1CN2C(CN3CCCC3)=NC4=CC=CC=C42.[H]Cl |
| InChI | 1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H |
| InChI key | DNFMJYXRIMLMBZ-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
