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LY 303511-CAS 154447-38-8-Calbiochem
| 产品编号： | 4061608 |
| 规格： | A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002. |
| CAS NO： | 154447-38-8 |
| 包装规格： | 1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
154447-38-8
LY 303511-CAS 154447-38-8-Calbiochem
2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor V, BRD3 Inhibitor IV, BRD4 Inhibitor V
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H18N2O2 |
| Molecular weight | 306.36 |
| General description【一般描述】 | A cell-permeable, negative control for the phosphatidylinositol-3-kinase (PI-3 kinase) inhibitor, LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not affect PI-3 kinase activity even at concentrations ≥100 µM. A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not inhibit PI 3-kinase even at a concentration of 100 µM. Shown to bind to the same site as I-BET (Cat. no. 401010) and reversibly inhibit BET bromodomain proteins BRD2, BRD3 & BRD4 (IC50 ~10 µM). |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Target IC50: Does not inhibit PI 3-kinase even at a concentration of 100 µM Product does not compete with ATP. Reversible: no Primary Target Negative control for the PI 3-kinase inhibitor LY 294002 |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. |
| Other Notes【其他说明】 | Dittman, et al. 2014. ACS Chem Biol.9, 495. Ding, J., et al. 1995. J. Biol. Chem.270, 11684. Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| color【颜色】 | amber |
| solubility【溶解性】 | DMSO: 100 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C19H18N2O2/c22-17-13-18(21-11-9-20-10-12-21)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13,20H,9-12H2 |
| InChI key | NGAGMBNBKCDCDJ-UHFFFAOYSA-N |
| packaging【包装】 | 1 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
