Akt Inhibitor-Calbiochem

C₃₀H₅₈O₁₀

578.78

A cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC₅₀ of 5.0 µM). Moderately inhibits PI 3-K activity (IC₅₀ = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC₅₀ values in the 1-10 µM range.
A cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC₅₀ of 5.0 µM). Moderately inhibits PI 3-K activity (IC₅₀ = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC₅₀ values in the 1 - 10 µM range.

Cell permeable: yes
Target IC₅₀: 5.0 µM for Akt (PKB)
Product competes with ATP.
Reversible: yes

Toxicity: Standard Handling (A)

Use anhydrous DMSO for reconstitution.
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.

Hu, Y., et al. 2000 J. Med. Chem.43, 3045.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (NMR)

solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)

white to off-white

DMSO: 200 mg/mL

ambient

−20℃

1 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1