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Caveolin-1 Scaffolding Domain Peptide, Cell-permeable-Calbiochem
| 产品编号： | 4061659 |
| 规格： | Caveolin-1 scaffolding domain peptide (C1-SD82-101) fused at the N-terminus to the cell-permeable Antennapedia internalization sequence (43-58). |
| 包装规格： | 1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Caveolin-1 Scaffolding Domain Peptide, Cell-permeable-Calbiochem
AP-Cav, Pen-C1-SD, RQIKIWFQNRRMKWKK-DGIWKASFTTFTVTKYWFYR, Cavtratin
基本信息
| Empirical Formula【经验(实验)分子式】 | C228H335N61O49S |
| Molecular weight | 4746.54 |
| General description【一般描述】 | Caveolin-1 scaffolding domain peptide (C1-SD82-101) fused at the N-terminus to the cell-permeable Antennapedia internalization sequence (43-58). This peptide is reported to block eNOS activity and cellular NO release in vitro and reduce inflammation and tumorigenesis in vivo. Caveolin-1 interacts with several lipid-modified signaling ligands, such as EGFR, eNOS, G-protein α-subunits, PKCα, H-Ras, and Src, via the C1-SD82-101 sequence. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target eNOS Product does not compete with ATP. Reversible: no |
| Warning【警告】 | Toxicity: Carcinogenic / Teratogenic (D) |
| Sequence【序列】 | H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Asp-Gly-Ile-Trp-Lys-Ala-Ser-Phe-Thr-Thr-Phe-Thr-Val-Thr-Lys-Tyr-Trp-Phe-Tyr-Arg-OH |
| Physical form【外形】 | Supplied as a trifluoroacetate salt. |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Bernatchez, P.N., et al. 2005. Proc. Natl. Acad. Sci. USA102, 761. Williams, T.M., et al. 2004. J. Biol. Chem.279, 51630. Gratton, J.P., et al. 2003. Cancer Cell4, 31. Sukumaran, S.K., et al. 2002. J. Biol. Chem.277, 50716. Liu, J., et al. 2002. J. Biol. Chem.277, 10661. Bucci, M., et al. 2000. Nat. Med.6, 1362. Okamoto, T., et al. 1998. J. Biol. Chem.273, 5419. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | lyophilized solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 2 mg/mL |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 1 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
