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Diclofenac Sodium-CAS 15307-79-6-Calbiochem
| 产品编号： | 4061669 |
| 规格： | A cell-permeable, non-selective cyclooxygenase inhibitor (IC50 = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity. |
| CAS NO： | 15307-79-6 |
| 包装规格： | 1 G |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4061669 | 1 G | 889 |
产品别名
15307-79-6
Diclofenac Sodium-CAS 15307-79-6-Calbiochem
2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H10Cl2NO2 · Na |
| Molecular weight | 318.13 |
| MDL number | MFCD00082251 |
| General description【一般描述】 | A potent non-steroidal anti-inflammatory drug that inhibits both COX-1 (IC50 = 76 nM) and COX-2 (IC50 = 26 nM) activities. Also inhibits liver phenol sulfotransferase activity (IC50 ~9.5 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. A cell-permeable, non-selective cyclooxygenase inhibitor (IC50 = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity. Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Also inhibits liver phenol sulfotransferase activity (IC50 = 9.5 µM). |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Target IC50: 60 nM and 200 nM for ovine COX-1 and COX-2 respectively; 9.5 µM against liver phenol sulfotransferase activity Primary Target COX-1 Product does not compete with ATP. Reversible: no |
| Warning【警告】 | Toxicity: Toxic & Carcinogenic / Teratogenic (G) |
| Reconstitution【重悬】 | Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Kato, M., et al. 2001. J. Pharm. Pharmacol.53, 1679. Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312. Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81. Merlos, M., et al. 1996. Inflamm. Res.45, 20. Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473. Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479. Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (TLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
| color【颜色】 | white |
| solubility【溶解性】 | water: 25 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 10-30℃ |
| InChI | 1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1 |
| InChI key | KPHWPUGNDIVLNH-UHFFFAOYSA-M |
安全信息
| Pictograms【象形图】 | GHS06,GHS08,GHS09 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H301 - H361d - H372 - H411 |
| Precautionary Statements | P201 - P202 - P260 - P264 - P273 - P301 + P310 |
| Hazard Classifications【危险分类】 | Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1 |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
