GSK-3 Inhibitor IX, Control, MeBIO-CAS 710323-61-8-Calbiochem

C₁₇H₁₂BrN₃O₂

370.20

A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as an inactive control for Cdk1/cyclin B, Cdk5/p25, and GSK-3α/β (IC₅₀ >92 µM for Cdk1/cyclin B, >100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC₅₀ = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.
A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as a relevant kinase inactive control (IC₅₀ >92 µM for Cdk1/B, >100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC₅₀ = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.

Cell permeable: yes
Primary Target
Relevant kinase inactive control
Product does not compete with ATP.
Reversible: no
Target IC₅₀: >92 µM for Cdk1/B, >100 µM for Cdk5/p25, and GSK-3α/β

Toxicity: Standard Handling (A)

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

dark red

DMSO: 10 mg/mL

ambient

2-8℃

1 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1