HBDDE-CAS 154675-18-0-Calbiochem

C₁₆H₁₈O₈

338.31

A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKC_α (IC₅₀ = 43 µM) and PKC_γ (IC₅₀ = 50 µM) over PKC_δ, β_I, and β_II isozymes in in vitro assays. Reported to induce apoptosis in rodent cerebellar granule neurons.
Protein kinase C (PKC) inhibitor. Selectively inhibits PKC_α (IC₅₀ = 43 µM) and PKC_γ (IC₅₀ = 50 µM) over PKC_δ, βI and βII isozymes.

Cell permeable: yes
Primary Target
PKCα
Target IC₅₀: 43 µM against PKCα
Product does not compete with ATP.
Reversible: no

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Mathur, A., and Vallano, M.L. 2000. Biochem. Pharmacol.60, 809.
Kashiwada, Y., et al. 1994. J. Med. Chem. 37, 195.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (TLC)

solid

Calbiochem^®

OK to freeze
protect from light

orange

ethanol: 1 mg/mL
warm water: 1 mg/mL
DMSO: 5 mg/mL

ambient

−20℃

1S/C16H18O8/c1-23-5-7-3-9(17)13(19)15(21)11(7)12-8(6-24-2)4-10(18)14(20)16(12)22/h3-4,17-22H,5-6H2,1-2H3

NEBCAMAQXZIVRE-UHFFFAOYSA-N

1 mg in Plastic ampoule

11 - Combustible Solids

WGK 1