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InSolution SB 202190-CAS 152121-30-7-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4061707 | 1 ML | 2820 |
产品别名
152121-30-7
InSolution SB 202190-CAS 152121-30-7-Calbiochem
InSolution p38 MAP Kinase Inhibitor II
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H14FN3O |
| Molecular weight | 331.34 |
| MDL number | MFCD00941964 |
| General description【一般描述】 | A potent and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (IC50 = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to block LDL expression in Hep52 cells. |
| Biochem/physiol Actions【生化/生理作用】 | Target Ki: 350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2) Primary Target P38β Reversible: yes Cell permeable: yes Product competes with ATP. |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 1 mg/ml solution of SB 202190 (Cat. No. 559388) in anhydrous DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-20°C). |
| Other Notes【其他说明】 | Ajizian, S.J., et al. 1999. J. Infect. Dis.179, 939. Singh, R.P., et al. 1999. J. Biol. Chem.274, 19593. Wang, S.W., et al. 1999. Inflamm. Res.48, 533. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem.5, 49. Jiang, Y., et al. 1996. J. Biol. Chem.271, 17920. Kramer, R.M., et al. 1996. J. Biol. Chem.271, 27723. Li, Z., et al. 1996. Biochem. Biophys. Res. Commun.228, 334. Lee, L.C., et al. 1994. Nature372, 739. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | liquid |
| potency【效能】 | 16 nM IC50 16 nM Ki |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,23-24H |
| InChI key | NJNKPVPFGLGHPA-UHFFFAOYSA-N |
| packaging【包装】 | 1 ml in Glass bottle Packaged under inert gas Please refer to vial label for lot-specific concentration. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - (Dimethylsulfoxide) |
| Flash Point(C)【闪点(C)】 | 87 ℃ - (Dimethylsulfoxide) |
