MMP-2/MMP-9 Inhibitor II-CAS 193807-60-2-Calbiochem

C₂₁H₂₀N₂O₄S

396.46

A potent inhibitor of MMP-2 (IC₅₀ = 17 nM) and MMP-9 (IC₅₀ = 30 nM). Also shown to potently induce and rapidly activate HIF. Reported to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.
A potent inhibitor of type IV collagenases, MMP-2 (IC₅₀ = 17 nM) and MMP-9 (IC₅₀ = 30 nM). Also shown to potently induce and rapidly activate HIF. Has been shown in vivo to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.

Primary Target
MMP-2
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Target IC₅₀: 17 nM, 30 nM against MMP-2, and MMP-9, respectively

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Lauzier, M.C., et al. 2008. Mol. Pharmacol.In press.
Mifune, M., et al. 2005. J. Biol. Chem.280, 26592.
Zhang, H., et al. 2004. Circ. Res.95, 989.
Tamura, Y., et al. 1998. J. Med. Chem.41, 640.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze

off-white

DMSO: 100 mg/mL
methanol: 25 mg/mL

ambient

−20℃

1 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1