您的位置:首页 > 产品中心 > Peroxynitrite-Calbiochem
Peroxynitrite-Calbiochem
产品编号: | 4061731 |
规格: | Synthesized from isoamyl nitrite and hydrogen peroxide. |
包装规格: | 1 SET |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品性质
Quality Level【质量水平】 | 100 |
form【形式】 | liquid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles protect from light |
color【颜色】 | yellow |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −70℃ |
packaging【包装】 | 1 set in Alu drum Packaged under inert gas |
基本信息
General description【一般描述】 | Synthesized from isoamyl nitrite and hydrogen peroxide. Peroxynitrite (ONOO–) is a cell-permeable strong biological oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine. Has been implicated in a variety of pathophysiological conditions including acute respiratory distress syndrome (ARDS), arthritis, atherosclerosis, inflammatory bowel disease, ischemia-reperfusion, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity, and septic shock. Synthesized from isoamyl nitrite and hydrogen peroxide. Peroxynitrite (ONOO–) is a strong biological oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine. It has been implicated in a variety of patho-physiological conditions including acute respiratory distress syndrome (ARDS), arthritis, atherosclerosis, inflammatory bowel disease, ischemia-reperfusion, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity, and septic shock. This product decomposes or isomerizes at pH 8 or less; the half-life at pH 7.5 is ~1.5 s. ε302 nm = 1670M-1cm-1 in 0.1 MNaOH. Note: 1 set = 2 x 1 ml. |
Biochem/physiol Actions【生化/生理作用】 | Primary Target Oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine Product does not compete with ATP. Cell permeable: yes Reversible: no |
Warning【警告】 | Toxicity: Oxidizer (K) |
Physical form【外形】 | Supplied in 4.7% NaOH at 160-200 mM. |
Preparation Note【制备说明】 | Peroxynitrite is soluble in aqueous buffers that have been pre-purged with an inert gas and pre-cooled to 4°C. |
Reconstitution【重悬】 | Protect from heat, light, metal ions, and air. Peroxynitrite is unstable; thaw rapidly, dispense into aliquots, purge tubes with an inert gas, and freeze -70°C. Activity decreases ~2% /day at -20°C. |
Other Notes【其他说明】 | Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA94, 14243. Sakuma, S., et al. 1997. Biochem. Biophys. Res. Commun. 230, 476. Lymar, S.V., et al. 1996. Biochemistry 35, 7855. Uppu, R.M., and Pryor, W.A. 1996. Methods Enzymol. 269, 322. Ischiropoulos, H., and al-Medhi, A.B. 1995. FEBS Lett. 364, 279. Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
安全信息
Pictograms【象形图】 | GHS05,GHS08 |
Signal word【警示用语:】 | Danger |
Hazard Statements | H290 - H314 - H341 - H351 |
Precautionary Statements | P202 - P234 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
Hazard Classifications【危险分类】 | Carc. 2 - Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Corr. 1B |
Storage Class Code【储存分类代码】 | 5.1B - Oxidizing hazardous materials |
WGK | WGK 2 |