Sodium Stibogluconate-CAS 16037-91-5-Calbiochem

C₁₂H₁₇O₁₇Sb₂ · 3Na · 9H₂O

907.88

A pentavalent antimony compound that forms a stable complex with and irreversibly inhibits Src homology protein tyrosine phosphatase (SHP-1) (99% inhibition at 11 µM). Also inhibits SHP-2 and PTP1B at an ~10-fold higher concentration (~110 µM). Does not inhibit the dual specificity protein tyrosine phosphatase (PTPase) or mitogen-activated protein kinase phosphatase-1 (MKP-1). Reported to induce general protein tyrosine phosphorylation and enhance IL-3-induced protein tyrosine phosphorylation of Jak2 and Stat5 in Baf3 cells. Also reported to augment IL-3-induced proliferation in Baf3 cells (EC_max = 44 µM) and GM-CSF-induced proliferation in TF-1 cells (EC_max = 55 µM). Exhibits anti-leishmanial effects.
A pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1) (99% inhibition at ~11 µM) by forming a stable complex. At higher concentrations (~110 µM), it inhibits SHP-2 and PTP1B activities.

Target IC₅₀: ~11 µM causing 99% inhibition of protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1)
Product does not compete with ATP.
Reversible: yes
Primary Target
PTPase activity, including Src homology PTPase-1 (SHP-1)
Cell permeable: no

Toxicity: Standard Handling (A)

Heating to 75°C with constant stirring or constant stirring overnight at room temperature may be required for complete solubilization.

Unstable in solution; reconstitute just prior to use.

Wortmann, G., et al. 2002. Clin. Infect. Dis.35, 261.
Pathak, M.K. and Yi, T. 2001. J. Immunol.167, 3391.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥90% dry basis (≥30% Sb content, titration)

solid

Calbiochem^®

OK to freeze
desiccated
protect from light

white

water: 1 mg/mL

ambient

2-8℃

1S/2C6H10O7.3Na.9H2O.3O.2Sb/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;;;;;;;;;;;;;;;;;/h2*2-5,7-8,10H,1H2,(H,12,13);;;;9*1H2;;;;;/q2*-2;3*+1;;;;;;;;;;;;;2*+2/p-2/t2*2-,3-,4+,5-;;;;;;;;;;;;;;;;;/m11................./s1

CUEDNFKBTFCOSV-UZVLBLASSA-L

1 g in Plastic ampoule
Packaged under inert gas

GHS07,GHS09

Warning

H302 + H332 - H411

P261 - P264 - P270 - P273 - P301 + P312 - P304 + P340 + P312

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2

11 - Combustible Solids

WGK 3