Cathepsin Inhibitor III-Calbiochem

C₂₇H₂₇N₃O₇

505.52

Cysteine protease inhibitor. Selectively inhibits cathepsin B (k₂/K_i = 1.0 x 10⁴ M^-1sec^-1), cathepsin L (k₂/K_i = 1.5 x 10⁵ M^-1sec^-1), cathepsin S (k₂/Ki = 6.6 x 10⁴ M^-1sec^-1), and papain (k₂/K_i = 1.0 x 10³ M^-1sec^-1). Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).
Cysteine protease inhibitor. Selectively inhibits cathepsin B (k₂/K_i = 1 x 10⁴ M^-1 sec^-1), cathepsin L (k₂/K_i = 1.5 x 10⁵ M^-1 sec^-1), cathepsin S (k₂/K_i = 6.6 x 10⁴ M^-1 sec^-1), and papain (k₂/K_i = 1 x 10³ M^-1 sec^-1).
Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).

Product does not compete with ATP.
k₂/K_i = 1 x 10⁴ M⁻¹ sec⁻¹
Primary Target
cathepsin B
Reversible: no
Cell permeable: no

Toxicity: Standard Handling (A)

Z-Phe-Gly-NHO-Bz-pOMe

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

>90% (HPLC)

solid

Calbiochem^®

OK to freeze
desiccated
protect from light

white

ethanol: 1 mg/mL
DMSO: 5 mg/mL

ambient

10-30℃

1 mg in Plastic ampoule

11 - Combustible Solids

WGK 1