IκB Kinase Inhibitor Peptide, Cell-Permeable-Calbiochem

C₁₃₈H₂₂₉N₃₇O₄₅S

3158.58

A 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence fused to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells (<50 µg/ml) and prevents NF-κB activation. Supplied as a trifluoroacetate salt.
A 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence, linked to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IkB kinases (IKK) in RAW 264.7 cells (<50 μg/ml) and prevents NF-κB activation.

Primary Target
LPS-induced IκB degradation by IKK in RAW 264.7 cells
Product does not compete with ATP.
Reversible: no
Target IC₅₀: <50 µg/ml for inhibiting LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells and prevents NF-κB activation
Cell permeable: no

Toxicity: Standard Handling (A)

Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ser-Gly-Leu-Asp-Ser-Met-Lys-Asp-Glu-NH₂

Supplied as a trifluoroacetate salt.

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Swaroop, N., et al. 2001. Pharm. Res.18, 1631.
Traenckner, E.B., et al. 1995. EMBO. J.14, 2876.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

lyophilized

Calbiochem^®

OK to freeze
desiccated (hygroscopic)
protect from light

PBS, pH 7.4: 1 mg/mL

wet ice

−20℃

1 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1