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InSolution GM 6001-Calbiochem
| 产品编号： | 4061856 |
| 规格： | InSolution |
| 包装规格： | 1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H28N4O4 |
| Molecular weight | 388.46 |
| General description【一般描述】 | A potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs in vitro [Ki = 0.4 nM for skin fibroblast collagenase (MMP-1); Ki = 0.5 nM for gelatinase A (MMP-2); Ki = 27 nM for stromelysin (MMP-3); Ki = 0.1 nM for neutrophil collagenase (MMP-8); and Ki = 0.2 nM for gelatinase B (MMP-9)]. Also prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Product does not compete with ATP. Reversible: no Primary Target MMP-1 Target Ki: 400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; and 200 pM for MMP-9 |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 10 mM (1 mg/257 µl) solution of GM6001 (Cat. No. 364205) in DMSO. |
| Reconstitution【重悬】 | Following initial use, aliquot and refrigerate (4°C). |
| Other Notes【其他说明】 | Solorzano, C.C., et al. 1997. Shock7, 427. Galardy, R.E., et al. 1994. Ann. NY Acad. Sci.732, 315. Galardy, R.E., et al. 1994. Cancer Res.54, 4715. Galardy, R.E., et al. 1993. Drugs Future18, 1109. Grobelny, D., et al. 1992. Biochemistry31, 7152. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 1 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - (Dimethylsulfoxide) |
| Flash Point(C)【闪点(C)】 | 87 ℃ - (Dimethylsulfoxide) |
