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InSolution KN-93-CAS 139298-40-1-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4061858 | 1 MG | 2820 |
产品别名
139298-40-1
InSolution KN-93-CAS 139298-40-1-Calbiochem
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H29ClN2O4S |
| Molecular weight | 501.04 |
| MDL number | MFCD03788201 |
| General description【一般描述】 | A cell-permeable, competitive inhibitor of Ca2+/calmodulin-dependent protein kinase II (Ki = 370 nM). Selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Product does not compete with ATP. Reversible: no Primary Target cam kinase 2 |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422708) in DMSO. |
| Reconstitution【重悬】 | Following initial thaw aliquot and freeze (-20°C). |
| Other Notes【其他说明】 | Fan, G.H., et al. 1999. Mol. Pharmacol.56, 39. Tombes, R.M., et al. 1995. Cell Growth Differentiation6, 1063. Chen, C., et al. 1994. Science266, 291. Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun.195, 608. Niki, I., et al. 1993. Biochem. Biophys. Res. Commun.191, 255. Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968. Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | liquid |
| potency【效能】 | 370 nM Ki |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+ |
| InChI key | LLLQTDSSHZREGW-AATRIKPKSA-N |
| packaging【包装】 | 1 mg in Plastic ampoule Packaged under inert gas |
