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InSolution PP1 Analog II, 1NM-PP1-CAS 221244-14-0-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4061861 | 1 MG | 2380 |
产品别名
221244-14-0
InSolution PP1 Analog II, 1NM-PP1-CAS 221244-14-0-Calbiochem
4-Amino-1-tert-butyl-3-(1'-naphthylmethyl)pyrazolo[3,4-d]pyrimidine
4-Amino-1- tert-butyl-3-(1'-naphthylmethyl)pyrazolo[3,4-d]pyrimidine
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H21N5 |
| Molecular weight | 331.41 |
| General description【一般描述】 | A cell-permeable and reversible PP1 analog (>Cat. No. 529579) that acts as a potent, selective, and ATP-competitive inhibitor of mutant kinases compared to the corresponding wild-type kinase (IC50 = 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIa-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µM for c-Abl). Shown to activate mutants of Ire1, a transmembrane kinase. A cell-permeable and reversible PP1 analog (>Cat. No. 529579) that acts as a potent, selective, and ATP-competitive inhibitor of mutant kinases compared to the corresponding wild-type kinase (IC50 = 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIa-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µM for c-Abl). Shown to activate mutants of Ire1, a transmembrane kinase. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target mutant c-Fyn, v-src, Cadk2, CaMKIIa, c-Abl etc., Target IC50: 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µ Reversible: yes |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 10 mM (1 mg/302 µL) solution of PP1 Analog II, 1NM-PP1 (Cat. No. 529581) in DMSO. |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -70°C. |
| Other Notes【其他说明】 | Ira, G., et al. 2004. Nature431, 1011. Papa, F.R., et al. 2003. Science302, 1533. Bishop, A.C., et al. 2000. Nature407, 395. Weiss, E.L., et al. 2000. Nat. Cell Biol.2, 677. Bishop, A.C., et al. 1999. J. Am. Chem. Soc.121, 627. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| packaging【包装】 | 1 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - Information refers to the main component. |
| Flash Point(C)【闪点(C)】 | 87 ℃ - Information refers to the main component. |
