Lactosyl Ceramide, Bovine-CAS 4682-48-8-Calbiochem

C₅₃H₁₀₁NO₁₃

960.37

MFCD00133445

A neutral glycosphingolipid (GSL) which is the common precursor of the ganglio-, globo-, globoiso-, lacto-, neolacto-, and muco- series of GSL. Promotes a time- and concentration-dependent proliferation of aortic smooth muscle cells via specific activation of p44 MAP kinase. Also stimulates Ras-GTP loading, MEK and Raf kinases, p44 MAP kinase and c-fos expression in human aortic smooth muscle cells.



Molecular weight: 960.4 (based on tricosanyl -23:0)
A neutral glycosphingolipid (GSL) that is the common precursor of the ganglio-, globo-, globoiso-, lacto-, neolacto-, and muco-series of GSL. Promotes a time- and concentration-dependent proliferation of aortic smooth muscle cells via specific activation of p44 MAP kinase. Also stimulates Ras-GTP loading, MEK and Raf kinases, p44 MAP kinase, and c-fos expression in human aortic smooth muscle cells.
M.W. 960.4 (based on tricosanoyl - 23:0).

Product does not compete with ATP.
Reversible: no
Primary Target
A neutral glycosphingolipid (GSL) that is the common precursor of the ganglio-, globo-, globoiso-, lacto-, neolacto-, and muco-series of GSL
Cell permeable: no

Toxicity: Irritant (B)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Bhunia, A.K., et al. 1997. J. Biol. Chem.272, 15642.
Bhunia, A.K., et al. 1996. J. Biol. Chem.271, 10660.
Zacharias, C., et al. 1994. J. Biol. Chem.269, 13313.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (TLC)

solid

Calbiochem^®

OK to freeze

colorless

ethanol: 1 mM
methanol: 1 mM

ambient

−20℃

1S/C48H91NO13/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-40(53)49-36(37(52)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2)35-59-47-45(58)43(56)46(39(34-51)61-47)62-48-44(57)42(55)41(54)38(33-50)60-48/h29,31,36-39,41-48,50-52,54-58H,3-28,30,32-35H2,1-2H3,(H,49,53)/b31-29+/t36?,37?,38-,39-,41+,42+,43-,44-,45-,46+,47-,48?/m1/s1

VOZHMDQUIRUFQW-AIRKALMMSA-N

1 mg in Plastic ampoule

11 - Combustible Solids

WGK 3