MAP Kinase Inhibitor Set II-Calbiochem

100

solid

2 μM IC₅₀

Calbiochem^®

OK to freeze
protect from light

ambient

−20℃

1 set in Glass bottle
Packaged under inert gas

Contains 5 mg of PD 98059 (Cat. No. 513000), 1 mg each of SB 203580 (Cat. No. 559389), and U0126 (Cat. No. 662005), and 1 mg of the negative control, SB 202474 (Cat. No. 559387).
The Mitogen-activated protein kinases (MAP Kinases) are a group of protein serine/threonine kinases that are activated in response to a variety of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. MAP kinases, in combination with several other signaling pathways can differentially alter phosphorylation status of the transcription factors that is unique to a given signal from outside the cell. A controlled regulation of these cascades is involved in cell proliferation and differentiation, whereas an unregulated activation of these MAP kinases can result in oncogenesis. Three major types of MAP kinase cascades have been reported in mammalian cells that respond synergistically to different upstream signals. They are ERK1/ERK2 MAP kinases, the JNK/SAPK (c-Jun kinase/stress activated protein kinase), and the p38 kinase.



The Calbiochem MAP Kinase Inhibitor Set II contains 4 inhibitors with different MAP Kinase specificities for your convenience.

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze

(-20°C).

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany