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Metastin (45-54)-Calbiochem
产品编号: | 4061877 |
规格: | A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors). |
包装规格: | 1 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Metastin (45-54)-Calbiochem
KiSS-1 (112-121), Kisspeptin-10, H-YNWNSFGLRF-NH2
基本信息
Empirical Formula【经验(实验)分子式】 | C63H83N17O14 |
Molecular weight | 1302.44 |
General description【一般描述】 | A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors). Induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (Ki = 42 pM) compared to Metastin (Cat. No. 445885). A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptor). More potent than the parent peptide. Induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (Ki = 42 pM, determined by competitive binding analysis) as compared to Metastin (Cat. No. 444885). |
Biochem/physiol Actions【生化/生理作用】 | Product does not compete with ATP. Reversible: no Target Ki: 42 pM for AXOR12 and hOT7T175 Cell permeable: no Primary Target AXOR12 and hOT7T175 |
Warning【警告】 | Toxicity: Standard Handling (A) |
Sequence【序列】 | H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ |
Other Notes【其他说明】 | Kotani, M., et al. 2001. J. Biol. Chem.276, 34631. Ohtaki, T., et al. 2001. Nature411, 613. Muir, A.I., et al. 2001. J. Biol. Chem.276, 28969. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥97% (HPLC) |
form【形式】 | lyophilized solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
color【颜色】 | white |
solubility【溶解性】 | DMSO: 5 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | −20℃ |
packaging【包装】 | 1 mg in Plastic ampoule Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 1 |