Raf Kinase Inhibitor IV-CAS 303727-31-3-Calbiochem

C₂₀H₁₄ClN₃O

347.80

MFCD12828750

A cell-permeable triarylimidazole compound that acts as a reversible, ATP-competitive, and highly potent inhibitor of Raf kinase (IC₅₀ = 10 nM & K_d = 2.4 nM for B-raf) with 7-, 30-, and 70-fold selectivity over p38α, GSK-3β, and Lck, respectively. Cellular data have indicated that the compound is more effective towards Raf-1and A-Raf than B-Raf.
A cell-permeable triarylimidazole compound that acts as a reversible, ATP-competitive, and highly potent inhibitor of Raf kinase (IC₅₀ = 10 nM and K_d = 2.4 nM for B-raf) with 7-, 30-, and 70-fold selectivity over p38α, GSK-3β, and Lck, respectively. Cellular data have indicated that the compound is more effective towards Raf-1and A-Raf than B-Raf.

Cell permeable: yes
Kd = 2.4 nM for B-raf
Product competes with ATP.
Reversible: yes
Primary Target
Raf Kinase

Toxicity: Irritant (B)

Takle, A.K., et al. 2006. Bioorg. Med. Chem. Lett.16, 378.
Shelton, J.G., et al. 2003. Leukemia17, 1765.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (HPLC)

solid

10 nM IC₅₀

Calbiochem^®

OK to freeze
protect from light

off-white

ethanol: 10 mg/mL
DMSO: 100 mg/mL

ambient

2-8℃

1 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 3