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γ-Secretase Inhibitor I-Calbiochem
产品编号: | 4063010 |
规格: | The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications. |
包装规格: | 1 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
γ-Secretase Inhibitor I-Calbiochem
Z-LLNle-CHO
基本信息
Empirical Formula【经验(实验)分子式】 | C26H41N3O5 |
Molecular weight | 475.62 |
General description【一般描述】 | Cell permeable. Inhibits γ-secretase, a protease that cleaves the Amyloid Precursor Protein (APP) to generate β-amyloid protein. Inhibition of this enzyme is believed to aid in the prevention of Alzheimer’s disease. Inhibits γ-secretase, a protease that cleaves the amyloid precursor protein (APP). Inhibition of this enzyme is believed to aid in the prevention of Alzheimer′s disease. |
Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target γ-secretase Product does not compete with ATP. Reversible: no |
Warning【警告】 | Toxicity: Standard Handling (A) |
Sequence【序列】 | Z-Leu-Leu-Nle-CHO (Nle = Norleucine) |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
Other Notes【其他说明】 | Skovronsky, D.M., et al. 2000. Biochemistry 39, 810. Hartmann, T., et al. 1997. Nat. Med. 3, 1016. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 200 |
Assay【测定】 | ≥90% (HPLC) |
form【形式】 | solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
color【颜色】 | white |
solubility【溶解性】 | DMSO: 10 mg/mL 50% acetic acid: soluble |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | −20℃ |
packaging【包装】 | 1 mg in Plastic ampoule Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 1 |