Granzyme B Inhibitor I-Calbiochem

C₁₉H₂₄ClN₃O₇

441.86

A weak inhibitor of the human and murine granzyme B. Also inhibits the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID₅₀ = 300 nM).
A weak inhibitor of the human and murine serine protease granzyme B. Also inhibits the apoptosis related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID₅₀ = 300 nM).

Cell permeable: yes
Target IC₅₀: 300 nM against the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2
Product does not compete with ATP.
Reversible: no
Primary Target
Granzyme B

Toxicity: Standard Handling (A)

Z-Ala-Ala-Asp-CH₂Cl

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Gong, B., et al. 1999. Cell Growth Different. 10, 491.
Shi, L., et al. 1992. J. Exp. Med. 176, 1521.
Odake, S., et al. 1991. Biochemistry30, 2217.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
desiccated

off-white

DMSO: 5 mg/mL

ambient

−20℃

1 mg in Plastic ampoule

11 - Combustible Solids

WGK 1