Complement C7 来源于人类血清

MFCD00130845

NA.75

The complement system is a complex cascade involving proteolytic cleavage of serum glycoproteins often activated by cell receptors. This cascade ultimately results in induction of the inflammatory response, phagocyte chemotaxis and opsonization, and cell lysis.

A complex of complements C5b, C6, C7, and C8 mediates the polymerization of up to eighteen C9 molecules into a tube-like membrane attack complex that is inserted into the plasma membrane of unwanted organisms, such as of Gram-negative bacteria and viral infected cells. This channel through the lipid bilayer results in lysis of the cell.

Human Complement C7 is a β-2-globulin, which is composed of a single polypeptide chain. The initial binding of C7 and C6 to C5b is thought to form a stable complex for subsequent binding of C8 and C9. The resulting activated complex is responsible for membrane attack and lysis.

Functionally active by a sensitive hemolytic assay.

200

human serum

≥85% (SDS-PAGE)

solution

≥150,000 C7H50 units/mg protein

1 mg/mL in 10 mM sodium phosphate, 150 mM sodium chloride, pH 7.2

activity assay: suitable

P10643

dry ice

−70℃

human ... C7(730)

12 - Non Combustible Liquids