PD 169316-CAS 152121-53-4-Calbiochem

C₂₀H₁₃FN₄O₂

360.34

MFCD12405019

A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.
A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀= 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.

Cell permeable: yes
Product competes with ATP.
Primary Target
p38 MAP kinase
Reversible: yes
Target IC₅₀: 89 nM against p38 MAP kinase

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Nath, R., et al. 2001. Cell Mol. Biol. Lett.6, 173.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

orange-yellow

DMSO: 10 mg/mL

ambient

−20℃

1 mg in Plastic ampoule

GHS05,GHS06

Danger

H301 - H315 - H318 - H335

P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Respiratory system

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK 3