抗-磷酸化皮层肌动蛋白 (pTyr ⁴⁶⁶ ) 兔抗

MFCD05665243

NA.41

Cortactin is encoded by the CTTN gene on chromosome 11 in humans. It is a cytoskeleton protein that facilitates assembly of cortical actin. It is expressed in most adherent cells and is a prominent substrate of protein-tyrosine kinase Src.

synthetic phosphopeptide derived from the region of mouse cortactin that is phosphorylated on tyrosine 466.

Anti-phospho-Cortactin (pTyr466) antibody produced in rabbit is suitable for western blotting at a concentration of 0.1-1.0μg/mL using NIH3T3 cells expressing activated c-Src.

Cortactin is activated by phosphorylation of tyrosine kinases or serine/threonine kinases. It plays an important role in promoting lamellipodia formation, invadopodia formation, cell migration, and endocytosis. Cortactin regulates the interactions between components of adherens-type junctions and helps in organizing the cytoskeleton, cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. It acts as a regulator in invasion and migration of tumor cells. The overexpression of cortactin causes osteosarcoma carcinogenesis and along with FAK increases the risk of oral premalignant lesions.

Solution in Dulbecco′s phosphate buffered saline (without Mg²⁺ and Ca²⁺), pH 7.3, containing 1.0 mg/ml BSA (IgG, protease free) and 0.05% sodium azide.

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen 80-85 kDa

mouse

western blot: 0.1-1.0 μg/mL using NIH3T3 cells expressing activated c-Src

Q60598

dry ice

−70℃

mouse ... Cttn(13043)

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WGK 3

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)