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Anti-phospho-Retinoblastoma (pSer780) antibody produced in rabbit
| 产品编号： | 4063704 |
| 规格： | affinity isolated antibody, buffered aqueous glycerol solution |
| 包装规格： | 0.1 ML |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD02097166 |
| NACRES | NA.41 |
| General description【一般描述】 | RB1 (RB transcriptional corepressor 1) codes for nuclear phosphoprotein pRB (retinoblastoma protein). It is located on human chromosome 13q14. It is a tumor-suppressor gene. |
| Specificity【特异性】 | Recognizes Rb phosphorylated at Ser780 and does not react with non-phosphorylated Rb. Does not react with Rb phosphorylated at other sites. |
| Immunogen【免疫原】 | synthetic peptide corresponding to residues around pSer780 of the human retinoblastoma tumor suppressor protein (Rb). |
| Biochem/physiol Actions【生化/生理作用】 | RB1 (RB transcriptional corepressor 1) plays an important role throughout G1/S phase transition. Absence of RB induces prostate cancer metastasis. It plays an important role in modulating the cell cycle. It also regulates cell stemness and differentiation. |
| Physical form【外形】 | Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin, and 50% glycerol. |
| Preparation Note【制备说明】 | Purified using protein A and affinity chromatography. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous glycerol solution |
| species reactivity | human, mouse, rat |
| technique(s) | western blot (chemiluminescent): 1:1,000 using human fibroblasts synchronized by serum deprivation |
| UniProt accession no.【UniProt登记号】 | P06400 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... RB1(5925) mouse ... Rb1(19645) rat ... Rb1(24708) |
