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CA-074 Me-Calbiochem
| 产品编号： | 4063716 |
| 规格： | CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B. |
| 包装规格： | 1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
CA-074 Me-Calbiochem
Cathepsin B Inhibitor IV, [L-3- trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H31N3O6 |
| Molecular weight | 397.47 |
| General description【一般描述】 | A cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro. A cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target cathepsin B Product does not compete with ATP. Reversible: no Target IC50: 2.24 nM against cathepsin B |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Sever, N., et al. 2002. Biol. Chem.383, 839. Authier, F., et al. 1999. J. Biol. Chem.274, 33723. Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118. Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 10 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 1 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
