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羧酸酯酶1 人
Carboxylesterase 1 isoform c human
| 产品编号： | 4063719 |
| 规格： | recombinant, expressed in baculovirus infected BTI insect cells |
| 包装规格： | 1 VIAL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
羧酸酯酶1 人
Carboxylesterase 1 isoform c human
Carboxylesterase 1 human
esterase
carboxylesterase
羧酸酯酶
酯酶
基本信息
| Enzyme Commission (EC) Number【酶学委员会(EC)编号】 | 3.1.1.1 ( BRENDA | IUBMB ) |
| EC number【EC 号】 | 232-773-7 |
| NACRES | NA.54 |
| General description【一般描述】 | Carboxylesterase 1 (CE1) is a member of a large multigene carboxylesterase α,β-hydrolase family. It is majorly expressed in the liver. CE1 comprises an αβ domain, a central catalytic domain and a regulatory domain. |
| Application【应用】 | Carboxylesterase 1 isoform c human has been used as a reference standard in carboxylesterase activity from the mussel for comparison of substrate specificity and inhibition studies. It has also been used as a commercial recombinant protein for the methodological validation of environmental chemical-based inhibition studies. |
| Biochem/physiol Actions【生化/生理作用】 | Carboxylesterase enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. Carboxylesterase 1 (CE1) catalyzes the formation of cholesteryl esters from cholesterol and fatty acids. Through a transesterification reaction, CE1 also mediates the generation of fatty acid ethyl esters (FAEEs). It also hydrolyzes aromatic and aliphatic esters with preference to small alcohol groups and bulky acyl groups. CE1 metabolizes drug esters and amides carbamates. It participates in the detoxification of environmental toxicants and carcinogens and is useful in pharmacokinetic studies for evaluating pro-drugs. |
| Physical properties【物理属性】 | This product is offered in a volume of 0.5 mL. |
| Unit Definition【单位定义】 | One unit will hydrolyze one nanomole of 4-nitrophenyl acetate per minute at pH 7.4 at 37 ℃. |
产品性质
| Quality Level【质量水平】 | 200 |
| recombinant【重组】 | expressed in baculovirus infected BTI insect cells |
| form【形式】 | liquid |
| Specific Activity | ≥1000 units/mg protein |
| concentration【浓度】 | 5 mg/mL |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
安全信息
| Pictograms【象形图】 | GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H334 |
| Precautionary Statements | P261 - P284 - P304 + P340 + P312 - P501 |
| Hazard Classifications【危险分类】 | Resp. Sens. 1 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
