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CIGB-300 trifluoroacetate
产品别名
2306481-24-1
CIGB-300 trifluoroacetate
P15-Tat trifluoroacetate
H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-βAla-Cys-Trp-Met-Ser-Pro-Arg-His-Leu-Gly-Thr-Cys-NH2 trifluoroacetate (Cys15-Cys25 disulfide)
H-GRKKRRQRRRPPQ-βA-CWMSPRHLGTC-NH2 trifluoroacetate (βA = β-alanine; C15-C25 disulfide)
CIGB-325 trifluoroacetate
基本信息
| Empirical Formula【经验(实验)分子式】 | C127H216N54O29S3 |
| Molecular weight | 3059.61 |
| Biochem/physiol Actions【生化/生理作用】 | CIGB-300 (P15-Tat) is a substrate-competitive casein kinase 2 inhibitor (CK2, CKII) composed of a membrane-permeant HIV-1 Tat protein transduction domain sequence (a.a. 48-60) N-terminal to a disulfide-bridged cyclic substrate peptide that inhibits against CK2-mediated substrate HPV-16 E7 phosphorylation in vitro. CIGB-300 exhibits cytotoxic effect in various cancer cultures (IC50 from 20 to 182 μM) via apoptosis induction and effectively inhibits TC-1 tumor growth in mice in vivo (48 μmol/200 μL/mouse via daily intratumoral injection). |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | film |
| color【颜色】 | white to off-white |
| storage temp.【储存温度】 | −20℃ |
