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Ionomycin calcium salt 钙盐
Ionomycin calcium salt
| 产品编号： | 4063780 |
| 规格： | Ready Made Solution, from Streptomyces conglobatus, 1 mM in DMSO |
| 包装规格： | 1 ML |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Ionomycin calcium salt 钙盐
Ionomycin calcium salt
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C41H70CaO9 |
| Molecular weight | 747.07 |
| EC number【EC 号】 | 200-664-3 |
| MDL number | MFCD00083634 |
| PubChem Substance ID【PubChem化学物质编号】 | 329815372 |
| NACRES | NA.85 |
| Application【应用】 | Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus. It has been shown to induce central demyelination , inhibit adrenal bovine TREK-1 channels , and to regulate cell division of mature human B cells . It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA. |
| Biochem/physiol Actions【生化/生理作用】 | Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+; non-fluorescent; used to study Ca2+ transport across biological membranes; induces apoptotic degeneration of embryonic cortical neurons. Ionomycin is a Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+. It is non-fluorescent. It is used to study Ca2+ transport across biological membranes and induces apoptotic degeneration of embryonic cortical neurons. |
产品性质
| Quality Level【质量水平】 | 300 |
| biological source【生物来源】 | Streptomyces conglobatus |
| Assay【测定】 | ≥98% (HPLC) |
| shelf life【保质期】 | 2 yr |
| concentration【浓度】 | 1 mM in DMSO |
| color【颜色】 | colorless |
| mp | 18.4 ℃ |
| antibiotic activity spectrum【抗生素抗菌谱】 | Gram-positive bacteria |
| Mode of action【作用机制】 | cell membrane | interferes |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | C[C@@H]1CCC(=O)O[Ca]OC(=CC(=O)[C@@H](C)C[C@@H](C)C1)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]2CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H](C)O |
| InChI | 1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-24-;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1 |
| InChI key | WKRWUYKLUMMAKG-WYGBAUISSA-L |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - closed cup |
| Flash Point(C)【闪点(C)】 | 87 ℃ - closed cup |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
