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Myelin Basic Protein Antigen from human brain
基本信息
| MDL number | MFCD03457654 |
| NACRES | NA.32 |
| General description【一般描述】 | Myelin basic protein (MBP) is an 18.5kDa protein encoded by the gene mapped to human chromosome 18q22qter. MBP is a major component of myelin sheath and is highly expressed in central nervous system (CNS). |
| Application【应用】 | Myelin basic protein antigen from human brain has been used in enzyme-linked immunosorbent spot assays. |
| Biochem/physiol Actions【生化/生理作用】 | Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). It also has a crucial role to play in human demyelinating diseases including multiple sclerosis (MS). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis. Determined using polyclonal and monoclonal antibodies against MBP. |
| Physical form【外形】 | Lyophilized from 10mM HCl. |
| Other Notes【其他说明】 | Blood samples from donors were tested and found to be negative for HBsAg, HIV-1 and HIV-2 antibodies, HCV. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | human brain |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| technique(s) | ELISA: suitable |
| UniProt accession no.【UniProt登记号】 | P02686 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... MBP(4155) |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
