NF-κB Activation Inhibitor-CAS 545380-34-5-Calbiochem

C₂₂H₂₀N₄O

356.42

MFCD06411436

A cell-permeable quinazoline compound that acts as a highly potent inhibitor of NF-κB transcriptional activation (IC₅₀ = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC₅₀ = 7 nM in murine splenocytes). Shown to exhibit anti-inflammatory effect on carrageenin-induced paw edema in rat. A 10 mM (1 mg/281 µl) solution of NF-κB Activation Inhibitor (Cat. No. 481407) in DMSO is also available.
A cell-permeable quinazoline compound that acts as a potent inhibitor of NF-κB transcriptional activation (IC₅₀ = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC₅₀ = 7 nM in murine splenocytes). Does not exhibit cellular cytotoxicity even at concentrations as high as 10 µM. Reported to exhibit anti-inflammatory effects on carregeenin-induced paw edema in rats.

Product does not compete with ATP.
Cell permeable: yes
Primary Target
NF-κB transcriptional activation
Reversible: no
Target IC₅₀: 11 nM against NF-κB transcriptional activation in Jurkat cells

Toxicity: Toxic (F)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Tobe, M., et al. 2003. Bioorg. Med. Chem.11, 383.
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CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

off-white

DMSO: 5 mg/mL

ambient

2-8℃

1 mg in Plastic Bag(s)
Packaged under inert gas

11 - Combustible Solids

WGK 3