人骨保护素/ TNFRSF11b ELISA试剂盒

NA.32

The Human Osteoprotegerin ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Osteoprotegerin in serum, plasma, cell culture supernatants and urine.

Osteoprotegerin (OPG) is encoded by the gene mapped to human chromosome 8q24. It is a member of the TNFR (tumor necrosis factor receptor) superfamily that can act as a decoy receptor for RANKL (receptor activator of nuclear factor kappa-B ligand) and TRAIL (tumor necrosis factor-related apoptosis-inducing ligand). OPG is expressed in a wide variety of tissues, including adult heart, lung, kidney and liver. It is secreted both as a monomeric and a dimeric protein.

Recombinant Human OPG

请参考Protocol了解详情。

Binding of soluble osteoprotegerin (OPG) to sRANKL (soluble receptor activator of nuclear factor κ-B ligand) inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells. This process leads to excess accumulation of bone and cartilage. Changes in the level of serum OPG are associated with atherosclerosis and cardiovascular disorders(CVDs). It might also be associated with malignancy and plays a regulatory role in multiple myeloma, prostate, breast, bladder and gastric carcinoma. OPG plays a vital role in bone metabolism and is involved in inhibition of ovariectomy-associated bone loss in rats. It is also used as a potent biomarker for CVD.

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组份可单独销售
RABELADA ELISA 1X Assay/Sample Diluent Buffer A (Item D1)
RABELADB ELISA 5X Assay/Sample Diluent Buffer B (Item E1)
RABSTOP3 ELISA Stop Solution (Item I)
RABTMB3 ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)
RABWASH4 20X Wash Buffer (Item B)

human

kit of 96 wells (12 strips x 8 wells)

ELISA: suitable
capture ELISA: suitable

sample type serum
sample type plasma
sample type urine
sample type cell culture supernatant(s)

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 1 pg/mL
standard curve range: 1.23-900 pg/mL

colorimetric

wet ice

−20℃

human ... TNFRSF11B(4982)

GHS05

Warning

H290

P234 - P390

Met. Corr. 1

8A - Combustible, corrosive hazardous materials

WGK 3