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4-Hydroxyphenylpyruvate Dioxygenase from Streptomyces avermitilis
基本信息
| Enzyme Commission (EC) Number【酶学委员会(EC)编号】 | 1.13.11.27 ( BRENDA | IUBMB ) |
| NACRES | NA.54 |
| General description【一般描述】 | 4-Hydroxyphenylpyruvate Dioxygenase (4-HPPD) is a key enzyme in the catabolism of tyrosine and phenylalanine. 4-HPPD catalyzes the synthesis of homogenistate (2,5-dihydroxyphenylacetate) from ρ-hydroxyphenylpyruvate and molecular oxygen. 4-HPPD also catalyzes the conversion of α-ketoisocaproate to Β-hydroxyisovalerate. 4-HPPD requires Fe2+ as an essential cofactor. Rat 4-HPPD has a minimum of 80% homology with human 4-HPPD. Rat 4-HPPD is expressed abundantly in hepatocytes. It is also expressed in kidney, particularly in epithelial cells of the proximal tubules and the distant tubules. 4-HPPD has been identified as a potential biomarker of drug-induced liver injury in rat studies. |
| Unit Definition【单位定义】 | One unit will oxidize 1 μmole of molecular oxygen per minute at pH 7.0, 25 ℃, in the presence of 4-hydroxyphenylpyruvate. |
产品性质
| Quality Level【质量水平】 | 200 |
| recombinant【重组】 | expressed in E. coli |
| form【形式】 | liquid |
| Specific Activity | ≥5 U/mg |
| mol wt【分子量】 | ~41.8 kDa |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
